The studies revealed that procyanidin directly inhibits the activities of MEK and MT-1 MMP, which are proteins critically involved in the progression of arteriosclerosis.
In experiments on smooth muscle cells, which control blood pressure in arteries and veins, procyanidin successfully shut down the activities of MEK and MT-1 MMP, preventing the progression of arterioslerosis induced by thrombin in the process.
Procyanidin was also found to suppress the expression of VEGF, a protein involved with the formation of new blood vessels to feed tumors, thus preventing normal cells from turning into cancer cells.
For the experiments, the research team used low concentrations of procyanidin at 1 to 3 ug/ml. For an adult weighing 60 kilograms, the level is achievable by eating an 80-gram bar of dark chocolate.
September 3, 2008
SNU PR Office
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