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Research Highlights

Research Highlights /

Research Highlights

Professor Yoon-Sik LEE Enables Direct Identification of Peptides Using SERS Barcoding System

Sep 29, 2020

Professor LEE Yoon-Sik
Professor LEE Yoon-Sik

Professor Yoon-Sik Lee’s research team (Dept. of Chemical and Biological Engineering) has developed a surface-enhanced Raman spectroscopic (SERS) barcoding system for high-throughput bioanalysis using highly sensitive SERS nanoparticles (SERS ID) which enables easy preparation and screening of compound libraries. The team combined 44 kinds of SERS IDs to generate more than a million codes. The SERS ID encoding based screening platform can identify the peptide ligand on the bead and also quantify its binding affinity for specific protein. The barcoding method showed high stability and reliability under bioassay conditions. “We believe that our SERS barcoding technology is a promising method in the screening of one-bead-one-compound (OBOC) libraries for drug discovery,” said Professor Lee.

Summary by LEE HeeUn, SNU English Editor, gurume0221@snu.ac.kr
Proofread by Melora Brett Briana Johnson, morningcalm2@gmail.com