Move to content body Move to content menus


  • home
  • sitemap
  • korean



Research Highlights

Professor Vic Narry KIM Deconstructs Structure of Human DROSHA

  • January 1, 2016
  • Hit 6877
    • facebook
    • twitter
    • print

Professor KIM Vic Narry
Professor KIM Vic Narryspan>

Professor V. Narry Kim (director of the Center for RNA Research, Institute for Basic Science) has reported the X-ray structure of DROSHA, a class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA (formerly RNASE) gene. DROSHA is a key factor in creating microRNA which functions in RNA silencing and regulation of gene expression. Professor Kim found that DROSHA contains two DGCR8-binding sites, one on each RNase III domain (RIIID), which mediate the assembly of Microprocessor. The overall structure of DROSHA is surprisingly similar to that of Dicer, suggesting that DROSHA may have evolved from a Dicer homolog. DROSHA exhibits unique features, including non-canonical zinc-finger motifs, a long insertion in the first RIIID, and the kinked link between Connector helix and RIIID. This research was published online in Cell on December 31, 2015.

Summary by LEE Hee Un, SNU English Editor,
Proofread by Melora Brett Briana Johnson,

List of postings
200 Professor SUH KyungSuk Saves High School Girl with Biliary Atresia and Later Helps Her Give Birth to a Child Jan. 25, 2016 7901
199 Professors HYEON Taeghwan and PARK Chung-Mo on the Thomson Reuters 2015 World's Most Highly Cited Researchers List Jan. 16, 2016 7235
198 Professor Young Ho YUN Leads Legislation of Well-dying Act Jan. 15, 2016 7579
197 Diabetic Pig Islet Transplant Recipients Report Normal Blood Glucose Level for up to 603 Days Jan. 5, 2016 5987
196 Professor Dae Hyeong KIM Develops Wearable Silicon Memory Array Jan. 2, 2016 7799